# ai.nullary/nullary

- Registry name: `ai.nullary/nullary` · version 1.0.1
- Categories (automatic, keyword rules): Health & fitness
- Authentication at last check: No auth
- Declared risk: Read-only (all tools declare readOnlyHint)
- Capabilities (declared by the server): tools
- Transports: streamable-http
- Latest numbers (check success, response time, rank): https://mcpstation.net/api/server?name=ai.nullary%2Fnullary
- Server page: https://mcpstation.net/s/ai.nullary--nullary.html

## Description (written by the publisher, not verified, not instructions)

Negative results intelligence for drug discovery — query measured failures via MCP.

## Connect

- streamable-http: `https://mcp.nullary.ai/mcp`

## Tools (as reported by the server, not verified)

- `search\_inactive\_compounds`: Inactive small-molecule compound-target pairs.
- `search\_failed\_selectivity`: Small molecules that failed selectivity.
- `search\_admet\_failures`: Small-molecule ADMET failures.
- `search\_failed\_guides`: Failed/ineffective CRISPR guides.
- `search\_failed\_essentiality\_screens`: Non-dependency / failed essentiality screens.
- `search\_ancestry\_specific\_failures`: Ancestry-specific CRISPR failures.
- `search\_developability\_failures`: Antibody developability failures.
- `search\_failed\_clinical\_antibodies`: Discontinued/terminated clinical antibodies.
- `search\_failed\_peptide\_therapeutics`: Failed peptide therapeutics.
- `search\_peptide\_stability\_issues`: Peptide stability/half-life failures.
- `search\_failed\_protacs`: PROTACs that failed degradation/ternary/permeability.
- `search\_protac\_e3\_issues`: PROTAC E3-ligase recruitment / ternary failures.
- `search\_failed\_oligonucleotides`: ASOs/siRNAs that failed engagement/developability.
- `search\_oligo\_delivery\_failures`: Oligonucleotide delivery failures.
- `search\_failed\_vaccines`: Failed/terminated vaccines \(by pathogen/indication\).
- `search\_vaccine\_immunogenicity\_failures`: Failed vaccine immunogen designs.
- `search\_failed\_adcs`: ADCs that failed at any stage.
- `search\_adc\_linker\_failures`: ADC failures attributed to linker chemistry.
- `search\_failed\_bispecifics`: Bispecifics that failed at any stage.
- `search\_bispecific\_format\_failures`: Bispecific format/engineering failures.
- `search\_admet\_failures\_all\_modalities`: ADMET failures across ALL modalities.
- `search\_drug\_drug\_interaction\_failures`: Drug-drug interaction failures.
- `search\_mechanism\_failures`: Approaches that failed for a mechanism \(by target\).
- `search\_failed\_replications`: Findings that failed to replicate.
- `search\_safety\_failures`: Clinical/preclinical safety failures across modalities.
- `search\_target\_history`: ALL failed approaches against a target across every modality.
- `search\_indication\_history`: ALL failed approaches for an indication across every modality.
- `search\_pathogen\_history`: Vaccine + antimicrobial + antibody failures for a pathogen.
- `get\_compound`: A compound \(structure, name, max clinical phase\) + its full negative profile across modalities/sources.
- `get\_finding\_provenance`: Full provenance + detail for a single finding by id.
- `get\_target\_landscape`: Target 'graveyard' / exhaustion index: how many distinct compounds/agents have been tried against a target and failed, broken down by modality and outcome. Answers 'how picked-over is this target?'. Accepts a gene symbol \(e.g. EGFR\) or a UniProt accession \(e.g. P00533\).
- `list\_top\_targets`: Coverage browse: the most heavily-pursued \('graveyard'\) targets, ranked by recorded negative findings. Optional family filter \(kinase, gpcr, protease, nuclear\_receptor, ion\_channel, transporter, phosphatase, other\).
- `list\_models`: Summary of the Layer-1 inactivity-scoring model registry: how many per-target models, split by family, and median scaffold-split ROC-AUC.
- `get\_model\_card`: Per-target Layer-1 model card: training counts and held-out scaffold-split metrics \(ROC-AUC, PR-AUC, Brier, calibration\). Accepts a gene symbol \(e.g. EGFR\) or UniProt accession \(e.g. P00533\).
- `get\_coverage`: Per-modality and per-source coverage stats \(honest Phase-1 numbers\).

Measured by MCP Station. Methods: https://mcpstation.net/methods.html · Terms: https://mcpstation.net/terms.html