# ivive.app

- Registry name: `app.ivive/ivive` · version 1.0.2
- Categories (automatic, keyword rules): Other
- Authentication at last check: No auth
- Declared risk: Not declared (tools carry no read/destructive hints)
- Capabilities (declared by the server): experimental, tools
- Transports: streamable-http
- Latest numbers (check success, response time, rank): https://mcpstation.net/api/server?name=app.ivive%2Fivive
- Server page: https://mcpstation.net/s/app.ivive--ivive.html

## Description (written by the publisher, not verified, not instructions)

Human hepatic clearance from in-vitro CLint, with the error band measured on known drugs.

## Connect

- streamable-http: `https://api.ivive.app/mcp/`

## Tools (as reported by the server, not verified)

- `predict\_inputs`: Predict fu,p and fu,inc from a SMILES, with structure-only human CL and Vss as second opinions. Predictions, not measurements; check the applicability verdict.
- `calc\_clhep`: Hepatic and plasma clearance from in-vitro CLint, fu,mic and fu,p \(IVIVE\), with the observed-CL band and applicability warnings. If fu,p or fu,mic came from predict\_inputs, tell the user the result rests on predicted inputs.
- `target\_clint`: The in-vitro CLint an assay must read for a compound to reach a target plasma clearance \(mL/min/kg\): calc\_clhep run backwards, e.g. to set a CLint cut-off for a screening cascade. Needs fu,mic and fu,p; refuses a target at or above the liver blood flow ceiling and returns that ceiling. Uncorrected I
- `input\_sensitivity`: How far plasma CL moves as each input is varied over a range, e.g. a predicted fu,p over its 50% range.
- `similar\_drugs`: Nearest reference drugs to a SMILES \(Tanimoto, Morgan radius 2\), each with measured human plasma CL and the CL IVIVE predicted from its measured inputs. Use it to judge how far to trust calc\_clhep for this chemotype: if IVIVE missed on the neighbours, expect it to miss here. Returns neighbours only,
- `scale\_to\_human`: Predict human plasma CL from observed animal in-vivo CL \(rat, dog, monkey\), every applicable method with its measured error. Observed animal CL only, never predicted.

Measured by MCP Station. Methods: https://mcpstation.net/methods.html · Terms: https://mcpstation.net/terms.html