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HLA-Verify

com.hlaverify/hla-verify · v1.0.1

Measured by MCP Station

Description written by the publisher, not verified

HLA nomenclature and match checks against a pinned IPD-IMGT/HLA release. No patient identifiers.

Connect

claude mcp add --transport http hla-verify https://api.hlaverify.com/mcp

{
  "mcpServers": {
    "hla-verify": {
      "url": "https://api.hlaverify.com/mcp"
    }
  }
}

Tools as reported by the server

• verify_text
  Scan HLA typing report text, or model output about HLA, for allele-shaped tokens and classify each one: valid / legacy spelling such as A*0201 or Cw*0702 (valid, with modern form and flag deprecated_name) / G-P group / deleted (with successor) / fabricated / NMDP MAC code (seen, not expanded) / KIR
• normalize_allele
  Normalize one reported HLA allele name (any era or reporting shorthand: legacy A*0101, Cw*0702 or Cw*07:02, G/P group names, A*02:XX, two-field A*02:01g, optional HLA- prefix) to current 2-field form, with G group, P group, serologic equivalent, and flags. NMDP MAC codes (A*02:AB) are recognised but
• allele_info
  Look up one name in the pinned release and return what it is: assigned (G/P group, first release, confirmed status, WMDA serology, null flag), valid_prefix (member count and sample, plus resolution: what a name with fewer than four fields does and does not distinguish), group (a G or P group name: m
• match_score
  Count a donor-recipient HLA match by the published counting rules (R1-R6): allele arithmetic over chromosomes, not a donor recommendation. recipient/donor: {"A": ["A*01:01","A*02:01"], "B": [...], ...} (two reported alleles per locus, any nomenclature era including G/P group names such as A*02:01:01
• check_typing
  QC-check one HLA typing (all loci) against the pinned release: resolves every reported allele, flags unresolvable/outdated/locus-mismatched/null alleles, flags too-many/single/homozygous per locus, computes the B-leader (-21 M/T) and KIR-ligand (C1/C2/Bw4) profile, and DRB3/4/5 expected-vs-reported.
• donor_compat
  Donor/recipient immunogenetic compatibility under two published rule sets: HLA-B leader match (-21 M/T, Petersdorf 2020) for a single HLA-B mismatch, and KIR ligand (C1/C2/Bw4) class comparison, computed over each side's full typing QC. Rule checking against published frameworks; it does not rank or
• validate_gl_string
  Validate and normalize a GL String (Genotype List, ^ | + ~ / grammar): resolves every allele token, flags outdated/unresolvable names and structural problems (mixed loci within a slash-list, a repeated locus within a haplotype or across ^ blocks, more than two haplotypes, differing loci across a gen
• pgx_lookup
  Which drugs an HLA typing carries a published pharmacogenomic association for. Looks each allele up in hla-pgx-open (CPIC guidelines + PharmGKB clinical annotations, CC BY-SA, snapshot date in every answer) after normalizing the name first, so any era or shorthand works (A*3101, B*5701, HLA-B*15:02:
• pgx_pair
  For a donor-recipient pair, which genome carries each actionable HLA-drug association. Screens both typings as pgx_lookup does and marks every CPIC level-A, allele-positive association in_recipient, in_donor, discordant (present in exactly one) and whose_hla (both / recipient_only / donor_only). Gui
• translate_names
  Translate HLA allele names from one IPD-IMGT/HLA release to another, through each allele's HLA ID, using the official Allelelist_history.txt (every release since 1.05.0). Give the names as they were written in release `from` (omit `from` to accept a name used in any release); `to` defaults to the cu
• release_diff
  Which HLA allele names were added, removed (with the deletion reason and successor) and renamed between two IPD-IMGT/HLA releases, optionally for one locus. Counts are complete; each list is cut at `limit` and `truncated` says so. Use it to see what a release update changes before re-running or re-r
• allele_history
  Every name the allele behind an HLA name has had, release by release since IPD-IMGT/HLA 1.05.0: its HLA ID, current name, the first and last release that used this name, the full timeline of names, and the deletion note if the name was retired. `as_of` adds what it was called in that release. Use it
• beta_signup
  Put a user on the free public beta's notification list for paid API keys. Ask before calling: it records the address they give you. Re-signing the same address is safe (status already_recorded). Someone who needs a higher rate limit today should email hello@hlaverify.com for a beta key instead of wa
• research_access
  Apply for free HLA-Verify access for an academic or nonprofit lab. Ask before calling: it records the address, institution and use case you give it. Approval is manual: a person reads every application, so it is not instant and not guaranteed. If it is approved the applicant is emailed a single-use
• about
  What this server is and is not, what to send it, benchmark evidence for why to use it, the beta state, and terms.

Tool changes

• 2026-10-17: verify_text, normalize_allele, allele_info, match_score, check_typing, donor_compat, validate_gl_string, pgx_lookup, pgx_pair, translate_names, release_diff, allele_history
• 2026-10-16: verify_text, normalize_allele, allele_info, match_score, check_typing, donor_compat, validate_gl_string, pgx_lookup, pgx_pair, beta_signup, research_access, about

Repository · Website · JSON · Text for agents · Registry updated 2026-09-16