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ai.nullary/nullary

ai.nullary/nullary · v1.0.1

Measured by MCP Station

Description written by the publisher, not verified

Negative results intelligence for drug discovery — query measured failures via MCP.

Connect

claude mcp add --transport http nullary https://mcp.nullary.ai/mcp

{
  "mcpServers": {
    "nullary": {
      "url": "https://mcp.nullary.ai/mcp"
    }
  }
}

Tools as reported by the server

• search_inactive_compounds
  Inactive small-molecule compound-target pairs.
• search_failed_selectivity
  Small molecules that failed selectivity.
• search_admet_failures
  Small-molecule ADMET failures.
• search_failed_guides
  Failed/ineffective CRISPR guides.
• search_failed_essentiality_screens
  Non-dependency / failed essentiality screens.
• search_ancestry_specific_failures
  Ancestry-specific CRISPR failures.
• search_developability_failures
  Antibody developability failures.
• search_failed_clinical_antibodies
  Discontinued/terminated clinical antibodies.
• search_failed_peptide_therapeutics
  Failed peptide therapeutics.
• search_peptide_stability_issues
  Peptide stability/half-life failures.
• search_failed_protacs
  PROTACs that failed degradation/ternary/permeability.
• search_protac_e3_issues
  PROTAC E3-ligase recruitment / ternary failures.
• search_failed_oligonucleotides
  ASOs/siRNAs that failed engagement/developability.
• search_oligo_delivery_failures
  Oligonucleotide delivery failures.
• search_failed_vaccines
  Failed/terminated vaccines (by pathogen/indication).
• search_vaccine_immunogenicity_failures
  Failed vaccine immunogen designs.
• search_failed_adcs
  ADCs that failed at any stage.
• search_adc_linker_failures
  ADC failures attributed to linker chemistry.
• search_failed_bispecifics
  Bispecifics that failed at any stage.
• search_bispecific_format_failures
  Bispecific format/engineering failures.
• search_admet_failures_all_modalities
  ADMET failures across ALL modalities.
• search_drug_drug_interaction_failures
  Drug-drug interaction failures.
• search_mechanism_failures
  Approaches that failed for a mechanism (by target).
• search_failed_replications
  Findings that failed to replicate.
• search_safety_failures
  Clinical/preclinical safety failures across modalities.
• search_target_history
  ALL failed approaches against a target across every modality.
• search_indication_history
  ALL failed approaches for an indication across every modality.
• search_pathogen_history
  Vaccine + antimicrobial + antibody failures for a pathogen.
• get_compound
  A compound (structure, name, max clinical phase) + its full negative profile across modalities/sources.
• get_finding_provenance
  Full provenance + detail for a single finding by id.
• get_target_landscape
  Target 'graveyard' / exhaustion index: how many distinct compounds/agents have been tried against a target and failed, broken down by modality and outcome. Answers 'how picked-over is this target?'. Accepts a gene symbol (e.g. EGFR) or a UniProt accession (e.g. P00533).
• list_top_targets
  Coverage browse: the most heavily-pursued ('graveyard') targets, ranked by recorded negative findings. Optional family filter (kinase, gpcr, protease, nuclear_receptor, ion_channel, transporter, phosphatase, other).
• list_models
  Summary of the Layer-1 inactivity-scoring model registry: how many per-target models, split by family, and median scaffold-split ROC-AUC.
• get_model_card
  Per-target Layer-1 model card: training counts and held-out scaffold-split metrics (ROC-AUC, PR-AUC, Brier, calibration). Accepts a gene symbol (e.g. EGFR) or UniProt accession (e.g. P00533).
• get_coverage
  Per-modality and per-source coverage stats (honest Phase-1 numbers).

Repository · JSON · Text for agents · Registry updated 2026-05-25