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ivive.app

app.ivive/ivive · v1.0.2

Measured by MCP Station

Description written by the publisher, not verified

Human hepatic clearance from in-vitro CLint, with the error band measured on known drugs.

Connect

claude mcp add --transport http ivive https://api.ivive.app/mcp/

{
  "mcpServers": {
    "ivive": {
      "url": "https://api.ivive.app/mcp/"
    }
  }
}

Tools as reported by the server

• predict_inputs
  Predict fu,p and fu,inc from a SMILES, with structure-only human CL and Vss as second opinions. Predictions, not measurements; check the applicability verdict.
• calc_clhep
  Hepatic and plasma clearance from in-vitro CLint, fu,mic and fu,p (IVIVE), with the observed-CL band and applicability warnings. If fu,p or fu,mic came from predict_inputs, tell the user the result rests on predicted inputs.
• target_clint
  The in-vitro CLint an assay must read for a compound to reach a target plasma clearance (mL/min/kg): calc_clhep run backwards, e.g. to set a CLint cut-off for a screening cascade. Needs fu,mic and fu,p; refuses a target at or above the liver blood flow ceiling and returns that ceiling. Uncorrected I
• input_sensitivity
  How far plasma CL moves as each input is varied over a range, e.g. a predicted fu,p over its 50% range.
• similar_drugs
  Nearest reference drugs to a SMILES (Tanimoto, Morgan radius 2), each with measured human plasma CL and the CL IVIVE predicted from its measured inputs. Use it to judge how far to trust calc_clhep for this chemotype: if IVIVE missed on the neighbours, expect it to miss here. Returns neighbours only,
• scale_to_human
  Predict human plasma CL from observed animal in-vivo CL (rat, dog, monkey), every applicable method with its measured error. Observed animal CL only, never predicted.

Tool changes

• 2026-10-22: predict_inputs, calc_clhep, target_clint, input_sensitivity, similar_drugs, scale_to_human
• 2026-10-18: predict_inputs, calc_clhep, target_clint, input_sensitivity, similar_drugs, scale_to_human

Website · JSON · Text for agents · Registry updated 2026-10-21